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The Prince, St Kilda – near the beach, fantastic spa (Aurora) and great restaurants (Circa on site), cafes, grittier part of town.
The Lyall, South Yarra – a great spa, quiet, leafy street, upmarket residential area, good shopping.
The Hatton, South Yarra – same area as The Lyall but very close to Botanical Gardens and even closer to the tram.
The Como Melbourne - MGallery Collection  – also South Yarra but on Chapel Street with excellent shopping. Good restaurants/cafes also nearby.
The Olsen/The Cullen/The Blackman – Art Series Hotels dotted around South Yarra, Prahran and inner city, named for famous Aussie artists with works exhibited throughout the hotels
Hotel Lindrum, CBD – recently joined M Gallery brand, on the edge of the CBD, close to MCG (great for cricket fans), city laneways and restaurants.